Metatranscriptomic analysis of the microbiota of tumor tissue in colon cancer - PubMed
3 hours ago
- #Oral-Gut Microbiota
- #Metatranscriptomics
- #Colorectal Cancer
- Metatranscriptomic analysis of tumor and control tissues (n=18 pairs) and subgingival sulcus (n=15) from CRC patients.
- Fusobacterium nucleatum was more active in tumor tissue and correlated with other oral bacteria (Parvimonas micra, Peptostreptococcus stomatis, Granulicatella adiacens) and gut bacteria (Hungatella hathewayi).
- Functional profile shift: higher expression of carbon metabolism genes in control tissue vs. amino acid-related genes in tumor tissue.
- Increased expression of lipopolysaccharide biosynthesis/transport genes and Fusobacterium nucleatum virulence factors in tumors.
- Correlation of Fusobacterium-Peptostreptococcus-Hungatella cluster with human inflammation and metastasis genes.
- Comparison of oral bacteria gene expression in gut vs. oral cavity: cluster partially shared, key virulence factors similarly expressed.
- Study reveals microbial activity in CRC tumors, links to oral microbiota, and implications for translocation, colonization, and tumorigenesis.