Heterogeneity of baseline immune activation and SARS-CoV-2 vaccine responses in people with HIV: a multicenter prospective study - PubMed
4 hours ago
- #HIV
- #Vaccine Response
- #Immune Activation
- Study compares SARS-CoV-2 mRNA vaccine responses in ART-treated people with HIV (PWH) versus HIV-negative controls.
- PWH had higher baseline levels of innate immune activation and endothelial inflammation markers than controls.
- Two inflammatory profile groups identified among PWH: Th1/Th17-oriented cytokine profile and monocyte activation/endothelial markers.
- Higher baseline inflammation in PWH linked to reduced humoral vaccine responses and decreased IFN-γ T-cell responses.
- In controls with prior SARS-CoV-2 exposure, higher inflammation markers correlated with stronger humoral and T-cell responses.