Early Transcriptional Changes in Neutrophil-Mediated Processes Following Recanalization After Ischemic Stroke - PubMed
8 hours ago
- #neutrophil activation
- #recanalization
- #biomarkers
- Early transcriptional changes post-recanalization reveal biomarkers like Il1r2, Cd55, Mmp8, Cd14, and Cd69.
- Vcan identified as a novel, conserved early biomarker across species (mice, rats, humans) following recanalization.
- Neutrophil elevation and activation pathways are key early responses, particularly upregulated in females.
- Regulatory factors include specific micro-RNAs and transcription factors such as NFE4 and MTF1.
- Study highlights a neutrophil-centered coregulatory network, offering insights into futile recanalization and potential therapies.