Confined migration induces non-lethal DNA damage in developing neurons - PubMed
4 hours ago
- #neuronal migration
- #brain development
- #DNA damage
- Confined migration in developing neurons causes massive DNA double-strand breaks (DSBs) from mechanostress in narrow spaces.
- These DSBs occur without nuclear envelope rupture and are repaired via non-homologous end-joining without cell death.
- DSBs tend to occur at transcriptionally inactive regions and are linked to topoisomerase-IIβ activity.
- Unrepaired DSBs in mutant mice lead to persistent damage, moderate gene expression changes, and mild motor deficits.
- DNA damage during neuronal migration may pose a disease risk if not properly repaired.