Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4-Mediated Acute Hepatitis - PubMed
5 hours ago
- #Acute hepatitis
- #TLR4
- #BDNF
- BDNF is consistently downregulated in hepatocytes during acute liver injury (ALI) and acute liver failure (ALF).
- Restoring BDNF, either endogenously or exogenously, alleviates LPS/DGal-induced ALI/ALF by antagonizing TLR4 on macrophages.
- A synthetic peptide, BDP12, derived from BDNF, shows strong anti-inflammatory effects and safety in models of acute hepatitis.