Toward informed batch correction for single-cell transcriptome integration - PubMed
5 days ago
- #transcriptome integration
- #single-cell RNA-seq
- #batch correction
- Review of data cleaning and integration methods for single-cell transcriptome data.
- Discussion on challenges with batch-correction algorithms, including overcorrection and undercorrection.
- Future frameworks aim to learn interpretable gene and cell representations for better modeling of technical and biological variation.
- Competing interests disclosed, including affiliations with Genentech, Bioptimus, and GlaxoSmithKline among others.
- References include key papers on single-cell RNA-seq scaling, batch effects, and data integration benchmarking.