Lower Muscarinic M1 Receptor Availability in Schizophrenia: In Vivo PET Evidence - PubMed
5 hours ago
- #muscarinic receptors
- #PET imaging
- #schizophrenia
- Lower muscarinic M1 receptor availability observed in schizophrenia patients compared to healthy controls.
- Significant deficits found across multiple brain regions: frontal (-13%), temporal (-15%), parietal (-14%), occipital (-16%), caudate (-19%), putamen (-19%), hippocampus (-13%), and amygdala (-19%).
- A subgroup of patients exhibited larger deficits (>20% from healthy control mean).
- Associations between M1 availability and selected clinical measures were explored.
- Findings highlight M1 as a therapeutic target and potential biomarker for muscarinic-based treatments.