Genetic associations and mediating effects of insulin resistance between hypertension and sarcopenia: A bidirectional two-sample Mendelian randomization study - PubMed
5 days ago
- #Insulin Resistance
- #Sarcopenia
- #Hypertension
- The study explores causal associations and mediating effects of insulin resistance (IR) between hypertension and sarcopenia.
- A bidirectional two-step Mendelian randomization (MR) was used, focusing on four sarcopenia-related traits: handgrip strength (HGS), appendicular lean mass (ALM), and usual walking pace (UWP).
- Hypertension showed a suggestive causality with reduced risk of UWP, with triglycerides mediating 6.985-13.666% of this effect.
- Decreased right HGS, left HGS, and ALM were associated with increased risk of hypertension.
- Insulin resistance (BMI, insulin, FBG, HbA1c, and TG) played a notable mediating role, accounting for 11.378-21.297% of the effect between HGS, ALM, and hypertension.
- The study provides genetic evidence linking hypertension and sarcopenia, emphasizing the importance of blood glucose, lipid, and weight control in managing both conditions.