Metabolic profiling reveals pyrimidine synthesis enzyme CAD as a central carbon metabolism signaling node in cancer cell proliferation - PubMed
6 hours ago
- #Cancer Metabolism
- #CAD
- #Deamidation
- Metabolic profiling identifies CAD as a key signaling node linking pyrimidine synthesis to central carbon metabolism in cancer cell proliferation.
- CAD deamidates and activates G6PD and PHGDH, rate-limiting enzymes of the PPP and SSP, enhancing metabolic flux.
- Activation of CAD correlates with a metabolic signature in diverse tumors, and simultaneous inhibition of G6PD and PHGDH impedes tumor formation.