Hepatic HuR modulates glucose metabolism through the C/EBPβ/PCK1 pathway - PubMed
6 hours ago
- #C/EBPβ/PCK1 pathway
- #type 2 diabetes
- #glucose metabolism
- Hepatic HuR modulates glucose metabolism via the C/EBPβ/PCK1 pathway.
- HuR expression is induced by metabolic challenges like fasting, caloric restriction, high-fat diet, and type 2 diabetes.
- HuR stabilizes Cebpb mRNA, enhancing PCK1 expression, a key gluconeogenic enzyme.
- Silencing hepatic Elavl1 (HuR) improves insulin sensitivity, glycemic control, and reduces adiposity in mice.
- HuR is identified as a potential therapeutic target for metabolic diseases.