Chemoprevention of hepatocellular carcinoma by next-generation antipsychotic aripiprazole - PubMed
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- #chemoprevention
- #aripiprazole
- #HCC
- Hepatocellular carcinoma (HCC) is a major global health concern with limited treatment options.
- Aripiprazole, an atypical antipsychotic, shows potential as a chemopreventive agent for HCC.
- Aripiprazole targets multiple liver cell types and modulates fibrogenesis and inflammation pathways.
- In animal models, aripiprazole prevents liver disease progression and HCC development.
- Mechanistically, aripiprazole inhibits cMET and ERK pathways and disrupts mitochondrial functions in cancer cells.
- Aripiprazole also modulates immune responses in the tumor microenvironment, as shown in patient-derived tumorspheroids.