Circadian disruption and its clinical implications in Parkinson's disease: A Narrative review - PubMed
6 hours ago
- #Parkinson's Disease
- #Circadian Rhythm
- #Sleep Disorders
- Circadian disruption in Parkinson's disease (PD) involves molecular mechanisms like altered clock genes (e.g., BMAL1) and melatonin signaling.
- Neuropathological changes in PD, such as suprachiasmatic nucleus involvement and α-synuclein deposition, contribute to circadian dysfunction.
- Circadian disruption in PD manifests as motor and non-motor symptoms, including sleep disorders, autonomic dysfunction, and depression.
- Therapeutic approaches include bright light therapy, melatonin agonists, and nonpharmacological strategies like sleep hygiene, exercise, and chronotherapy.
- Dopaminergic medications may influence circadian rhythms, and future research aims to normalize sleep disorders and improve quality of life in PD patients.