Targeting BMP2 signaling pathway in osteogenesis and osteoarthritis: A path toward safer regenerative therapies - PubMed
6 hours ago
- #Regenerative Therapy
- #Osteoarthritis
- #BMP2
- BMP2 is a key regulator in the TGF-β superfamily, crucial for skeletal development by guiding mesenchymal stem cells (MSCs) toward osteogenic and chondrogenic lineages.
- BMP2 activates both canonical SMAD1/5/8 cascades and non-canonical MAPK pathways (ERK, p38, JNK), enhancing transcriptional programs like Runx2 to stimulate extracellular matrix synthesis, bone regeneration, and cartilage differentiation.
- Recombinant BMP2 (rhBMP2) is used clinically in spinal fusion and fracture repair but has limitations due to its paradoxical biology, including promoting inflammation and cartilage degradation, which are hallmarks of osteoarthritis (OA).
- Current strategies focus on fine-tuning BMP2 activity to preserve its regenerative benefits while minimizing pathological effects, using methods like endogenous antagonists, receptor decoys, selective BMPR1 blockade, controlled delivery systems, and combination therapies.
- A deeper understanding of BMP2 signaling dynamics is essential for developing safer therapeutic approaches for osteoarthritis management.