A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR - PubMed
5 hours ago
- #cancer therapy
- #RNA editing
- #EZH2
- EZH2 regulates A-to-I RNA editing and mRNA stability in prostate cancer through its interaction with ADAR.
- EZH2 competes with ILF2 for binding to ADAR1, altering ADAR1's substrate selectivity and affecting editing bidirectionally.
- Depletion of EZH2 leads to translational repression of TRN1, causing cytoplasmic accumulation of ADAR1p110 to protect oncogenic transcripts.
- ADAR1 depletion enhances sensitivity of cancer cells and tumors to EZH2 selective degraders.
- The study links histone modification and RNA editing, showing EZH2's role in RNA processes independent of its methyltransferase activity.