Roseburia inulinivorans increases muscle strength - PubMed
2 days ago
- #probiotics
- #muscle strength
- #gut microbiota
- Roseburia inulinivorans is positively associated with muscle strength measures like handgrip, leg press, and bench press in humans.
- Supplementation of R. inulinivorans in mice significantly enhanced forelimb grip strength, unlike other Roseburia species.
- Metabolomic analyses showed R. inulinivorans reduces amino acid concentrations in the caecum and plasma while activating the purine and pentose phosphate pathway in muscle.
- R. inulinivorans increases muscle fiber size and shifts from type I to type II fibers.
- The relative abundance of R. inulinivorans is lower in older adults compared to young adults.
- R. inulinivorans is identified as a species-specific modulator of muscle strength, linking gut microbiota to muscle metabolism and function.
- Potential probiotic candidate for nutraceutical interventions targeting age-related muscle-wasting diseases.