Association Between Metabolic Score for Insulin Resistance (METS-IR) and Risk of Infertility: Evidence from NHANES 2013-2020 and Mendelian Randomization Study - PubMed
3 days ago
- #insulin resistance
- #Mendelian randomization
- #infertility
- Infertility affects approximately 15% of couples globally, with insulin resistance (IR) identified as a possible risk factor.
- The study explores the association between Metabolic Score for Insulin Resistance (METS-IR) and infertility risk using NHANES 2013-2020 data and Mendelian randomization (MR) analysis.
- Women with infertility had significantly higher METS-IR values (47.56±1.33) compared to non-infertile women (41.42±0.44, P<0.0001).
- The highest METS-IR quartile showed increased infertility risk (OR 1.53, 95% CI 1.24-5.21, P=0.04), with a non-linear relationship observed.
- MR analysis revealed causal relationships between triglycerides (IVW OR: 1.149), BMI (IVW OR: 0.967), and inflammatory markers (IL-18 and CXCL11) with infertility risk.
- The findings suggest metabolic and inflammatory factors contribute to reproductive dysfunction, highlighting the potential utility of metabolic assessment in fertility evaluation.