Platelet RIP2 Limits Dense Granule Release and Thrombosis via DOCK8-Cdc42 - PubMed
5 hours ago
- #myocardial infarction
- #platelet activation
- #thrombosis
- RIP2 deficiency enhances platelet dense granule secretion and increases platelet aggregation and adhesion.
- RIP2 inhibitor WEHI-345 potentiates human platelet dense granule secretion and inhibits RIP2 phosphorylation.
- Lower RIP2 expression is observed in platelets from patients with coronary artery disease and mice with atherosclerosis.
- RIP2 deficiency worsens myocardial infarction and cardiac function in a mouse ischemia/reperfusion model.
- A novel pathway p-RIP2-DOCK8-Cdc42 suppresses dense granule release downstream of GPIb and GPVI activation.