Pancreatic islet α cell function and proliferation require the arginine transporter SLC7A2 - PubMed
4 hours ago
- #SLC7A2
- #α cell proliferation
- #arginine transport
- SLC7A2 is highly expressed in pancreatic islet α cells and is crucial for arginine transport.
- Arginine and SLC7A2 are required for α cell proliferation, especially when glucagon signaling is interrupted.
- SLC7A2 deficiency leads to reduced glucagon and insulin secretion in response to arginine.
- SLC7A2 mediates arginine activation of mTOR signaling and induces the glutamine transporter SLC38A5.
- Genetic variants in SLC7A2 are associated with HbA1c levels, linking it to glucose metabolism regulation.