Reduced-dose total skin electron beam radiotherapy in mycosis fungoides and Sézary syndrome: Systematic review and meta-analysis - PubMed
3 days ago
- #mycosis fungoides
- #quality of life
- #TSEBT
- Reduced-dose total skin electron beam therapy (TSEBT) achieves a pooled overall response rate (ORR) of 91% and complete response rate (CRR) of 26% in mycosis fungoides (MF) and Sézary syndrome (SS).
- The most common toxicities are grade 1 and 2 skin reactions, indicating minimal risk of severe adverse events.
- Quality of life (QoL) significantly improves in one or more subdomains following reduced-dose TSEBT, based on studies evaluating its impact.
- Consolidation therapy after TSEBT, used by 38% of patients, is associated with improved progression-free survival (PFS) in most trials compared to monotherapy.
- Knowledge gaps persist on optimizing prolonged benefits, highlighting the need for investigating maintenance therapy for sustained remission.