The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome - PubMed
21 hours ago
- #Mitochondrial DNA
- #IGF-1 Signaling
- #Aging
- Reduced IGF-1 signaling extends mammalian lifespan and protects against age-related diseases.
- In mitochondrial mutator mice, reduced IGF-1 signaling does not extend lifespan, and longevity pathways are blocked or blunted.
- The longevity benefits of IGF-1 suppression depend on mitochondrial genome integrity, highlighting its crucial role in aging pathways.
- These findings reveal a hierarchy in aging control mechanisms and emphasize the need to preserve mitochondrial genome integrity.