Small heterodimer partner protects against osteoarthritis by inhibiting IKKβ/NF-κB-mediated matrix-degrading enzymes in chondrocytes - PubMed
10 hours ago
- #NR0B2
- #NF-κB signaling
- #osteoarthritis
- Small heterodimer partner (SHP, NR0B2) is identified as a novel catabolic regulator in osteoarthritis (OA) pathogenesis.
- NR0B2 expression is significantly reduced in OA patient cartilage.
- Deletion of Nr0b2 in mice worsens OA symptoms, while overexpression protects against OA progression.
- NR0B2 inhibits IKKβ kinase activity, downregulating NF-κB signaling and reducing matrix-degrading enzymes like MMP-3 and MMP-13.
- Gene therapy targeting Nr0b2 shows potential as a therapeutic strategy for OA.