Antigen-specific adaptive immunity in Parkinson's disease: peripheral priming, brain-border reactivation and parenchymal injury - PubMed
4 hours ago
- #T cells
- #Parkinson's disease
- #adaptive immunity
- The review discusses antigen-specific adaptive immunity in Parkinson's disease, highlighting peripheral priming, brain-border reactivation, and parenchymal injury.
- Two main antigen-specific routes are examined: α-synuclein/HLA-II/CD4+ T-cell route with evidence from human T-cell reactivity and border-associated macrophages, and mitochondrial antigen/MHC-I/CD8+ T-cell route linked to PINK1-Parkin dysfunction.
- The review suggests trafficking mechanisms from diseases like multiple sclerosis and viral encephalitis as useful pathways for PD studies, and considers viral antigens in brain-resident CD8+ T-cell pools.