Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases - PubMed
4 days ago
- #gut-brain axis
- #Mendelian randomization
- #genetic correlation
- Study investigates genetic correlations and causal relationships between intestinal and neurological diseases.
- Positive global genetic correlations found between irritable bowel syndrome and epilepsy, and stroke.
- Local genetic correlations identified between ulcerative colitis and multiple sclerosis in a specific genome region.
- 12 novel pleiotropic SNPs shared between intestinal and neurological diseases discovered.
- Functional gene shared between ulcerative colitis and multiple sclerosis identified.
- SNP heritability enrichment analysis shows immune cell involvement in ulcerative colitis and multiple sclerosis.
- Mendelian randomization indicates causal effect of Crohn's disease on Parkinson's disease.
- Methylome Mendelian randomization reveals causal relationships between several intestinal and neurological diseases.
- Findings support the 'gut-brain axis' theory and highlight the immune system's role.