Prospective Genomic Profiling of Consecutive Meningiomas - PubMed
5 hours ago
- #molecular biomarkers
- #meningioma
- #genomics
- The cIMPACT-NOW update 8 provides clarifications on molecular risk parameters and recommendations for WHO grading of meningiomas.
- Correlations between genomic subgroup and clinical features have been studied in a large cohort of over 3000 meningiomas.
- Genomic analysis of non-NF2 meningiomas reveals mutations in genes such as TRAF7, KLF4, AKT1, and SMO.
- Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.
- A targeted gene expression biomarker has been developed to predict recurrence in clinically low-risk meningiomas.