HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease - PubMed
4 days ago
- #Alzheimer's disease
- #HDAC6
- #neuroinflammation
- HDAC6 regulates BACE1 stability by deacetylating its C-terminal lysine (K501), increasing Aβ production in Alzheimer's disease.
- HDAC6 promotes NLRP3 inflammasome activation in microglia, leading to increased IL-1β production.
- HDAC6 deficiency in 5xFAD mice reduces BACE1 accumulation, Aβ deposition, and neuroinflammation, improving cognitive performance.
- Transcriptomic analysis shows HDAC6 deficiency downregulates disease-associated microglial and neurotoxic astrocyte signatures while enriching synaptic pathways.
- HDAC6 is identified as a dual regulator of Aβ production and neuroinflammation, making it a potential therapeutic target for Alzheimer's disease.