Dexmedetomidine inhibits fear memory consolidation via the astrocyte-specific Srebf1-Phgdh pathway in the prelimbic prefrontal cortex - PubMed
5 hours ago
- #PTSD
- #Dexmedetomidine
- #Fear Memory
- Dexmedetomidine at sub-anesthetic doses alleviates fear in mice by inhibiting fear memory consolidation.
- Srebf1 is identified as a key mediator of dexmedetomidine's effects, with reduced nuclear translocation in astrocytes.
- Downregulation of Srebf1 target gene Phgdh decreases D-serine synthesis, affecting synaptic stability and fear memory.
- The study provides a mechanism for dexmedetomidine's preventive use and identifies new targets for PTSD intervention.