Cytotoxic CD4+ T cells: origin, biological functions, diseases and therapeutic targets - PubMed
3 days ago
- #T cells
- #immunology
- #therapeutics
- Cytotoxic CD4+ T cells are a unique subset with cytokine secretion and cytolytic activity.
- They exhibit cytotoxicity similar to CD8+ T cells, showing functional plasticity in CD4+ T cells.
- These cells play roles in cancer, infectious diseases, autoimmune disorders, and cardiovascular diseases.
- They mediate inflammatory responses and kill target cells, maintaining immune homeostasis.
- Recent advancements have improved understanding of their diversity, regulation, differentiation, and functions.
- Therapeutic strategies targeting cytotoxic CD4+ T cells are being explored in clinical trials.