Loss of Brain-Derived Estrogen Is Associated With Sex- and Age-Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression - PubMed
4 hours ago
- #Estrogen
- #Brain Aging
- #Alzheimer's Disease
- Brain estrogen loss affects memory, affective behavior, and hippocampal extracellular matrix expression in a sex- and age-dependent manner.
- Old female mice with brain-specific or total aromatase knockout show spatial working memory and social interaction impairments, and depression-like behavior in female tArKO mice.
- Hippocampal RNA-seq reveals enrichment of extracellular matrix pathways in old female brain-specific aromatase knockout mice, with upregulation of genes like Col1a1 and Ccn2.