AI-Driven discovery of brain-penetrant mTOR-independent autophagy enhancers for Alzheimer's disease - PubMed
4 hours ago
- #Autophagy Enhancers
- #Alzheimer's Disease
- #AI Drug Discovery
- AI platform DeepDrugDiscovery identified mTOR-independent autophagy enhancers Ombuin and 2-Hydroxycinnamic acid for Alzheimer's disease.
- These compounds cleared tau and amyloid-β aggregates and restored memory in worm and mouse models, with Ombuin showing good brain penetrance.
- The approach focuses on mechanism-centric drug discovery, overcoming limitations of poor blood-brain barrier penetration and broad mTOR-related side effects.
- DeepDrugDiscovery has been released as an open-source resource to support scalable AI-driven therapeutic discovery.