Src-dependent tyrosine-phosphorylation of NM2A has a protective role against bacterial pore-forming toxins - PubMed
4 hours ago
- #phosphorylation
- #host defense
- #bacterial toxins
- Src-dependent tyrosine-phosphorylation of NM2A protects against bacterial pore-forming toxins (PFTs).
- Listeriolysin O (LLO) from Listeria monocytogenes triggers Src activation, leading to NMHC2A phosphorylation at tyrosine 158.
- NMHC2A phosphorylation is crucial for cytoskeletal reorganization and efficient responses to plasma membrane damage.
- Conserved phosphorylation in C. elegans NMY-2 (tyrosine 163) is essential for survival under PFT-induced stress and heat shock.
- The study reveals an evolutionarily conserved defense mechanism linking PFT-induced damage sensing to actomyosin remodeling.