Extracellular Vesicle-Mediated Nucleolin Transfer in Glioblastoma: A Targetable Axis Driving Blood-Tumour Barrier Formation - PubMed
21 hours ago
- #Blood-Tumour Barrier
- #Glioblastoma Therapy
- #Extracellular Vesicles
- Glioblastoma-derived extracellular vesicles transfer nucleolin to brain endothelial cells, promoting blood-tumour barrier formation.
- The aptamer AS1411 exploits nucleolin to cross the blood-tumour barrier and enter glioblastoma cells via receptor-mediated transcytosis.
- AS1411-based PROTACs targeting VEGFR2 and EGFR induce nucleolin- and MDM2-dependent degradation, showing anti-tumour activity in glioblastoma.