Ramulus mori (Sangzhi) alkaloids improve intestinal oxidative damage and inflammation in DHEA-induced polycystic ovary syndrome rats via gut microbiota and metabolite modulation - PubMed
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- #PCOS
- #oxidative stress
- #gut microbiota
- Ramulus mori (Sangzhi) alkaloids (SZ-A) improve intestinal oxidative damage and inflammation in DHEA-induced PCOS rats.
- SZ-A treatment reduces cystic follicles, restores estrous cyclicity, and improves metabolic markers like testosterone, bile acids, and insulin resistance.
- SZ-A remodels gut microbiota composition and serum metabolite profiles, with Lactobacillus and Treponema_2 as key genera.
- SZ-A reduces oxidative stress markers (MDA) and increases antioxidant capacity (T-AOC, SOD, GSH-Px).
- SZ-A suppresses systemic inflammation by lowering IL-6, IL-1β, and TNF-α levels.
- Fenoldopam is identified as a potential mediator of SZ-A's beneficial effects on ovarian function and metabolic homeostasis.