Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown - PubMed
6 hours ago
- #microbiome
- #lipid-metabolism
- #lysosomal-function
- Microbial tryptophan metabolism activates host lysosomal activity to facilitate lipid breakdown.
- Bacterial tryptophan metabolite indole enhances lysosomal function in both Caenorhabditis elegans and mammalian hepatocytes.
- Escherichia coli tryptophan catabolism via tryptophanase TnaA induces lysosomal lipid chaperone LBP-8, promoting lipid mobilization.
- Indole enhances lysosomal acidification and degradation capacity, while genetic disruption of lysosomal regulators reverses these effects.
- Bacterial tryptophan metabolism promotes mitochondrial β-oxidation through lysosomal lipase activity.
- This pathway is conserved in mammalian hepatocytes, where indole reduces lipid accumulation.
- The study highlights microbiota-regulated lysosomal activation as a potential therapeutic target for metabolic disorders.