SGO1 and SGO2 are Associated With Disease Progression and an Immunosuppressive Microenvironment in Papillary Renal Cell Carcinoma - PubMed
4 hours ago
- #immunosuppressive microenvironment
- #papillary renal cell carcinoma
- #tumor progression
- SGO1 and SGO2 proteins are involved in chromosome cohesion and segregation, with abnormal expression linked to cancers.
- This study explores their role in papillary renal cell carcinoma (KIRP), focusing on tumor progression and immune evasion.
- Analysis used multi-omics data from TCGA, GTEx, GEO, plus single-cell transcriptomics, immunohistochemistry, and functional assays.
- SGO1 and SGO2 are upregulated in KIRP, associated with advanced tumor stage and poor overall survival.
- Knockdown experiments show both proteins promote proliferation, migration, and invasion in renal cancer cells.
- Gene enrichment links SGO1/SGO2 to E2F signaling, genomic stability, and immune-related pathways.
- High expression correlates with increased immunosuppressive cell infiltration (regulatory T cells, M2 macrophages, etc.), suggesting an immune-evasive microenvironment.
- Findings indicate SGO1 and SGO2 are potential prognostic biomarkers and targets for further mechanistic studies.