Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A - PubMed
5 hours ago
- #colonic senescence
- #NAT10
- #elderly-onset colitis
- Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
- NAT10 and DYRK1A are upregulated in ulcerative colitis tissues from elderly patients and correlate with disease severity.
- Knockdown of NAT10 or treatment with Nat10/Dyrk1a inhibitors alleviates colitis in aged mice.
- NAT10 stabilizes DYRK1A mRNA through ac4C modification, driving colon epithelial senescence.
- Modulating NAT10-mediated RNA ac4C modification could rejuvenate intestinal aging and provide a therapeutic strategy for elderly-onset colitis.