Loss of U11/U12 spliceosome gene ZCRB1 leads to aberrant ciliogenesis and WNT signaling - PubMed
3 hours ago
- #WNT signaling
- #spliceosome
- #ciliogenesis
- Loss of ZCRB1, a core U12-dependent spliceosome gene, causes abnormal splicing and expression changes in minor intron-containing genes.
- Reduced ZCRB1 expression leads to disrupted ciliogenesis and upregulation of WNT signaling components in human cell lines.
- Knockdown of zcrb1 in zebrafish embryos results in developmental abnormalities, disrupted ciliogenesis, and increased WNT signaling, showing cross-species conservation.