UBA1 promotes cardiac hypertrophy by suppressing autophagy via targeting ATG5 for ubiquitination - PubMed
5 hours ago
- #Autophagy
- #Cardiac Hypertrophy
- #Ubiquitination
- UBA1 is upregulated in hypertrophic hearts and promotes cardiac hypertrophy.
- UBA1 suppresses autophagy by targeting ATG5 for ubiquitination and degradation.
- Knockdown of UBA1 protects against cardiac hypertrophy, fibrosis, and dysfunction.
- Overexpression of UBA1 exacerbates cardiac hypertrophy and related pathologies.
- ATG5 deletion nullifies the protective effects of UBA1 knockdown.
- UBA1 is proposed as a therapeutic target for hypertrophic cardiomyopathy.