Chaperone-mediated autophagy supports organ regeneration and fibroblast quiescence in mouse models of fibrosis - PubMed
2 days ago
- #regeneration
- #fibrosis
- #autophagy
- Chaperone-mediated autophagy (CMA) supports organ regeneration and inhibits fibrosis in mouse models.
- LAMP2A, a CMA limiting factor, is down-regulated in various fibrosis models and human fibrotic diseases.
- Overexpression of LAMP2A inhibits fibrosis progression and reverses myofibroblast activation by degrading integrin subunit beta 1.
- LAMP2A promotes regeneration in liver, lungs, and kidneys in fibrotic mouse models.
- Pharmacological activation of CMA alleviates established fibrosis and promotes functional recovery.
- LAMP2A is identified as a broad-spectrum antifibrotic factor with potential therapeutic applications.