As SuperAgers age, they make at least twice as many new neurons as their peers
6 hours ago
- #cognitive aging
- #brain health
- #neurogenesis
- SuperAgers maintain memory abilities comparable to people decades younger, even into their 80s and beyond.
- Their brains generate two to two and a half times more new neurons in the hippocampus than typical older adults and those with Alzheimer's.
- The study identified a unique 'resilience signature' in SuperAgers' hippocampi that supports neurogenesis and cognitive resilience.
- Key cell types, astrocytes and CA1 neurons, were found to drive cognitive health, with genetic programs remaining active in SuperAgers but switched off in Alzheimer's.
- This research, using advanced single-cell sequencing, suggests potential drug targets to prevent cognitive decline and supports the development of therapies for healthy aging.