Vascular Calcification and Heart Failure: A Bidirectional Mendelian Randomization and Mediation Analysis - PubMed
a day ago
- #Vascular calcification
- #Mendelian randomization
- #Heart failure
- Vascular calcification (VC) significantly increases the risk of heart failure (HF), with subtypes like coronary artery calcification (CAC), abdominal aortic calcification (AAC), and calcific aortic valve stenosis (CAVS) showing varying impacts on HF subtypes.
- Heart failure also promotes the progression of vascular calcification, indicating a bidirectional causal relationship between VC and HF.
- Atrial fibrillation (AF) partially mediates the causal effect of CAVS on overall heart failure (HFall), with a mediation proportion of 21.65%.
- Early detection and management of VC are crucial for HF prevention and treatment, especially in high-risk populations like those with ischemic heart disease.
- Screening and intervention for AF may be key to blocking the 'VC → AF → HF' pathway, offering new genetic evidence for HF prevention and treatment.