Effect of time-of-day vaccination on the antibody response to mRNA and protein COVID-19 vaccine in adults - PubMed
7 hours ago
- #antibody response
- #circadian rhythm
- #vaccine timing
- Morning vaccination with mRNA COVID-19 vaccine (Moderna) resulted in higher antibody responses to all SARS-CoV-2 variants at day 28 post-vaccination compared to afternoon vaccination.
- Time-of-day vaccination effects differed by sex in the mRNA vaccine group, with males showing higher antibody responses after morning vaccination, while females' responses were unaffected.
- No effect of time-of-day vaccination was observed on antibody responses to the protein-based COVID-19 vaccine (Novavax), regardless of sex.
- The study highlights the need for larger randomized trials to confirm these findings and optimize vaccine timing strategies.