Sensory Nerve-Derived CGRP Controls Osteoclastogenesis by Limiting Macrophage Bioenergetics in Bone Repair - PubMed
5 hours ago
- #immunometabolism
- #osteoclastogenesis
- #bone repair
- Sensory nerves play a crucial role in bone healing by suppressing excessive osteoclastogenesis.
- Calcitonin gene-related peptide (CGRP), derived from sensory nerves, modulates macrophage activation by restricting functions like migration, phagocytosis, and pro-inflammatory cytokine production.
- CGRP constrains ATP synthesis and mitochondrial respiration in macrophages, leading to downregulation of genes related to oxidative phosphorylation and mitochondrial complex components.
- Macrophages exposed to CGRP show reduced osteoclastogenic capacity and decreased secretion of factors supporting osteoclast differentiation and survival.
- The findings highlight a neuro-immune-metabolic axis in bone healing, emphasizing the potential of sensory signals in therapeutic strategies for bone regeneration.