Integrated single-cell and spatial transcriptomic analysis reveals mCAF-SPP1⁺ macrophage-T cell crosstalk shaping immunosuppressive niches in colorectal cancer liver metastasis - PubMed
14 hours ago
- #Colorectal cancer
- #Immunosuppression
- #Liver metastasis
- Integrated single-cell and spatial transcriptomic analysis reveals mCAF-SPP1 macrophage-T cell crosstalk in colorectal cancer liver metastasis.
- The study identifies immunosuppressive niches shaped by interactions between cancer-associated fibroblasts (mCAFs), SPP1-positive macrophages, and T cells.
- Ethics approval was not required as the study used de-identified data from public databases like TCGA and GEO.
- The authors declare no competing interests.
- References include global cancer statistics and studies on colorectal cancer liver metastasis pathogenesis and therapy.