Preclinical and Emerging Clinical Evidence Supporting the Translational Potential of GLP-1 Receptor Agonists for Treating Psychostimulant and Nicotine Use Disorders - PubMed
a day ago
- #translational research
- #substance use disorders
- #GLP-1 receptor agonists
- Preclinical evidence suggests GLP-1 receptor agonists may be repurposed to treat psychostimulant and nicotine use disorders.
- GLP-1R agonists show efficacy in reducing drug-mediated behaviors in animal models for these disorders.
- The review discusses the neural mechanisms, including the role of central endogenous GLP-1 circuits in drug-taking and seeking.
- Emerging clinical studies support the translational potential of GLP-1R agonists as novel treatments for substance use disorders.