Redox rhythms promote fitness by modulating ageing-dependent reprogramming - PubMed

5 hours ago

Redox rhythms, which are disrupted in aging, improve health by modulating age-related reprogramming.
Restoring redox oscillations through timed antioxidants/pro-oxidants enhances glucose metabolism, motor function, and tissue health in aged mice.
Redox rhythms partially rejuvenate liver transcriptome and chromatin accessibility, involving redox modification of the CLOCK protein at cysteine 195.
Perturbing CLOCK's redox-sensitive site leads to premature aging and hepatic reprogramming, suggesting redox-based interventions for healthy aging.

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