Targeting DYRK1A with Harmine Abrogates the FOXO1-NF-κB Axis to Alleviate Cellular Senescence and Renal Fibrosis - PubMed
4 hours ago
- #DYRK1A
- #Cellular Senescence
- #Renal Fibrosis
- Harmine, a DYRK1A inhibitor, mitigates renal fibrosis by alleviating tubular epithelial cell senescence.
- DYRK1A promotes FOXO1 phosphorylation, disrupting mitochondrial fatty acid β-oxidation and leading to cellular senescence.
- Hypoxia induces lipid accumulation and senescence in HK-2 cells, while Harmine reverses these effects in UUO mice.
- Clinical data show DYRK1A/FOXO1 expression correlates with fibrosis severity and lipid accumulation in CKD patients.
- The study identifies the DYRK1A-FOXO1-NF-κB axis as a key regulatory network in renal fibrosis.