Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development - PubMed
5 hours ago
- #endocrine-exocrine crosstalk
- #obesity
- #pancreatic cancer
- Beta cell-derived cholecystokinin (CCK) drives obesity-associated pancreatic adenocarcinoma (PDAC) development.
- Obesity induces expansion of immature β cells that adapt to express CCK via stress-responsive JNK/cJun signaling.
- CCK expression, rather than insulin, strongly correlates with enhanced tumorigenesis in PDAC.
- Obesity perturbs CCK-dependent peri-islet exocrine cell transcriptional states and enhances islet-proximal tumor formation.
- The study identifies endocrine-exocrine CCK signaling as a key driver of obesity-associated PDAC development.