Effectiveness, Comparative Effectiveness, and Harms of COVID-19 Vaccines in Adults Who Are Not Pregnant or Immunocompromised: A Rapid Review for the American College of Physicians - PubMed
4 hours ago
- #vaccine effectiveness
- #Omicron variant
- #COVID-19
- Effectiveness and harms of COVID-19 vaccines in nonpregnant, nonimmunocompromised adults were reviewed.
- Omicron-adapted vaccines likely reduce all-cause mortality and COVID-19-related hospitalizations (moderate certainty of evidence).
- Effectiveness is higher when administered more than 365 days after prior vaccination.
- Omicron-adapted vaccines may increase myocarditis risk in adults aged 50+ (low certainty of evidence).
- mRNA-1283.222 bivalent vaccine shows no difference in all-cause mortality or serious adverse events compared to mRNA-1273.222.
- Limited evidence on harms and no RCTs comparing Omicron-adapted vs. non-Omicron-adapted vaccines.