Unlocking an Efficient SOD-to-CAT Catalytic Relay in a MOF Nanozyme via Dopamine-Driven Interfacial Nanoreconstruction for Osteoarthritis Therapy - PubMed
a day ago
- #ROS scavenging
- #nanozyme
- #osteoarthritis
- The study introduces a novel 'pre-embedding/activation' strategy to enhance the therapeutic efficacy of cobalt-based MOF nanozymes for osteoarthritis (OA) treatment.
- Dopamine-driven interfacial nanoreconstruction remodels Zn/Co-N coordination sites, unlocking an efficient SOD-to-CAT catalytic relay for full-chain ROS scavenging.
- The enhanced nanozyme restores mitochondrial function and reprograms macrophages to an anti-inflammatory M2 phenotype by inhibiting the ROS-mediated S100A8/NF-κB signaling axis.
- In a rat OA model, the treatment promotes chondrocyte anabolism for cartilage repair and suppresses peripheral nerve sensitization for sustained pain relief.
- The research establishes nanoscale interfacial reconstruction as a platform for engineering sophisticated catalytic relays in nanozymes for advanced biomedical applications.