Combined Maternal and Offspring Vitamin D3 Supplementation Ameliorates Autism-Like Behaviors via VDR Pathway Activation, Neuroinflammatory Suppression, and Metabolic Homeostasis Restoration - PubMed
6 hours ago
- #autism spectrum disorder
- #neuroinflammation
- #vitamin D3
- Combined maternal and offspring vitamin D3 supplementation significantly improved autism-like behaviors, including social deficits, anxiety, and repetitive behaviors, in a 'dual-hit' mouse model of ASD.
- The supplementation upregulated VDR pathway activation in the brain, reduced neurotoxic metabolites, and lowered pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α.
- It restored metabolic homeostasis by modulating TMLHE expression and function, suggesting potential for vitamin D in ASD prevention and intervention.